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Why nephrotic syndrome often accompanied by hypoproteinemia

Dec 26, 2016
Definition of low serum albumin
Reduction of total plasma protein, especially plasma albumin. Hypoproteinemia is not an independent disease, but the result of nitrogen balance caused by various reasons. Main manifestations of malnutrition. The proteins in blood are mainly plasma proteins and hemoglobin contained in red blood cells. Plasma proteins include plasma albumin, globulin, fibrinogen and a small number of binding proteins such as glycoproteins, lipoproteins, etc., the total amount of 6.5 ~ 7.8g%. If the total plasma protein is lower than 6.0g%, it can be diagnosed as hypoproteinemia.
Causes of hypoproteinemia in patients with nephrotic syndrome
1, normal kidney blood albumin metabolism principle
Normal kidney filtration and reabsorption of protein, can make a lot of useful protein is not easy to drain. When the body of normal kidney, albumin by glomerular filtration membrane filtration, most cannot penetrate the glomerular filtration membrane, even if there were some proteins through the protein through the filtration membrane, will also be the renal tubular reabsorption to absorb most, only a few proteins to form primary urine, eventually excreted in the urine. The liver is a synthetic protein factory, will supplement the lost protein, has reached the normal metabolism of protein in blood balance.
2, liver damage during liver compensatory albumin metabolism principle
But when the glomerular basement membrane in human kidney damage, increased glomerular permeability, resulting in protein loss in capillaries, which is mainly albumin, such a large number of proteins excreted in the urine, proteinuria. The liver is the body protein factory, albumin is produced by the liver and kidney when damaged, a large number of proteins with loss of urine, thus stimulating the liver compensatory function, accelerate the synthesis of albumin, albumin content to maintain normal blood.
3, kidney damage when the liver synthesis protein is insufficient, blood albumin metabolism lose balance principle
Human liver albumin synthesis, albumin metabolism out of balance principle because of renal cells have been damaged, glomerular filtration membrane permeability increasing, more and more blood loss within the protein, when entering the body and liver protein synthesis in the lack of compensatory loss, blood protein decreased and the formation of hypoproteinemia, because in urine the loss of the protein is mainly albumin, so the main feature is that the decreased serum albumin, hypoalbuminemia.

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