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What are the causes of nephrotic syndrome

Dec 26, 2016
Nephrotic syndrome is also known as nephropathy, is due to a variety of causes lead to increased glomerular permeability in children, so that a large number of proteins in the plasma leak into the urine, resulting in a large number of proteins in the urine. However, nephrotic syndrome is not a strange disease, and now many factors in life are caused by the cause of nephrotic syndrome.

1, infection: bacterial infection in nephritis after streptococcal infection, bacterial endocarditis, shunt nephritis, leprosy, syphilis, tuberculosis, chronic pyelonephritis with reflux nephropathy; virus infection in hepatitis B, cytomegalovirus, infectious mononucleosis syndrome, human immunodeficiency virus infection in Plasmodium parasites increased; filariasis, toxoplasmosis, worm schistosomiasis.
2, drug poisoning, or allergy: organic or inorganic organic mercury, gold and silver, penicillamine, two heroin, probenecid, non steroidal anti-inflammatory drugs, trimethadione, drugs such as bee sting; snake venom; allergic pollen, vaccine, anti toxin.
3, systemic disease: systemic lupus erythematosus, mixed connective tissue disease, dermatomyositis, Sjogren syndrome, allergic purpura, amyloidosis. 4, metabolic diseases: diabetes, thyroid disease.
5, hereditary disease: congenital nephrotic syndrome, Alport syndrome, Fabry disease, sickle cell anemia, nail patella syndrome - fat, malnutrition, familial nephrotic syndrome etc..
6, malignant tumors: all kinds of malignant tumors can cause nephrotic syndrome, even with nephrotic syndrome as early clinical manifestations. Such as breast cancer, lung cancer, stomach cancer, colon cancer and lymphoproliferative diseases often occur nephrotic syndrome.
7, diabetic nephropathy: more than occurred in patients with diabetes for more than 10 years, especially diabetic type and not satisfied with the control of 1. A large number of proteinuria and nephrotic syndrome, fundus examination, there are more micro aneurysms, early renal volume increases, renal plasma flow and glomerular filtration rate increased or normal, late renal dysfunction. Many nephrotic syndrome patients trace the cause of nephrotic syndrome is the result of tiny nephropathy.
8, purpura nephritis: predilection in young people, clinical manifestations of nephrotic syndrome, renal manifestations of the main extremities of the distal purpura, abdominal pain, arthralgia, etc..
9 、 systemic lupus erythematosus: lupus nephritis more common in 20~40 years old women, 20%~50% presents the clinical manifestations of nephrotic syndrome. Patients with fever, rash and joint pain, especially facial sphenoid erythema has diagnostic value.
10, secondary nephrotic syndrome: infection, drug (mercury, organic gold, penicillamine and heroin), toxin and allergy, cancer (lung, stomach, colon, breast tumors and lymphoma), systemic lupus erythematosus, allergic purpura amyloidosis and diabetes. 1 / 3 of adult nephrotic syndrome and 2 of children can be caused by secondary factors.

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