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What are the symptoms of nephrotic syndrome you know?

May 11, 2017

What is nephrotic syndrome? I believe that many of my friends are not very understanding, after all, we are not professional medical people, for the disease are not very understanding, but now the disease is more scary, so more understanding of nephrotic syndrome, there is nothing not good. First, nephrotic syndrome is caused by a variety of causes, mostly because of glomerular basement membrane permeability increased. Suffering from this disease, there will be hypoproteinemia, a high degree of edema, hyperlipidemia and so on the syndrome. So simple to introduce, or not comprehensive enough, the following Beijing Tong Shantang Chinese medicine hospital carefully for you to introduce kidney disease syndrome, hoping to help you friends friends.

A large number of proteinuria is the most important clinical manifestations of NS patients, but also the most basic pathophysiology of nephrotic syndrome. A large number of proteinuria refers to adult urine protein excretion> 3.5g / d. In normal physiological conditions, glomerular filtration membrane with molecular barrier and charge barrier, resulting in increased protein content in the original urine, when far more than the proximal tubule back to the amount of absorption, the formation of a large number of proteinuria. On this basis, where the increase in glomerular pressure and lead to high perfusion, high filtration factors (such as high blood pressure, high protein diet or a large number of infusion of plasma protein) can increase the discharge of urine protein.

Plasma albumin down to <30g / L. NS is a large number of albumin lost from the urine, promote albumin liver compensatory synthesis and increased renal tubular decomposition. Low albuminemia occurs when liver albumin synthesis is not sufficient to overcome loss and breakdown. In addition, NS patients due to gastrointestinal mucosal edema caused by eating loss, lack of protein intake, poor absorption or loss, but also increase the causes of hypoalbuminemia. In addition to plasma albumin reduction, some plasma immunoglobulin (such as IgG) and complement components, anticoagulant and fibrinolytic factors, metal binding protein and endocrine binding protein can also be reduced, especially a large number of proteinuria, glomerular Pathological damage is more severe and non-selective proteinuria is more significant. Patients prone to infection, hypercoagulable, lack of trace elements, endocrine disorders and immune dysfunction and other complications.

NS hypoalbuminemia, plasma colloid osmotic pressure decreased, so that water from the vascular cavity into the tissue gap, is the basic cause of NS edema. Recent studies have shown that about 50% of patients with normal or increased blood volume, plasma renin levels normal or decreased, suggesting that some of the primary renal sodium, water retention factors in the NS edema mechanism play a role.

To understand the symptoms of nephrotic syndrome, early detection of disease signals, early treatment, to restore health.

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