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The cause of nephrotic syndrome

Dec 27, 2016
All along, it is believed that with age, the emergence of physiological kidney deficiency is normal. However, more and more people into the ranks of the early kidney deficiency, the reason, more and more kidney disease are caused by bad habits, such as rhythm of life, unhealthy diet, excessive drinking, stay up late at night, is the modern people face fierce competition pressure is not a choice the. Stay up late for a long time, not only affects a person's spirit, but also prone to dark circles, the spirit of drowsiness, fatigue, loss of kidney essence, lead to kidney deficiency.
The cause of nephrotic syndrome, nephrotic syndrome is caused by various causes is introduced, with massive proteinuria, hypoalbuminemia, edema, hyperlipidemia and other symptoms of clinical characteristics of a group of symptoms, according to its causes can be pided into primary nephrotic syndrome and secondary nephrotic syndrome. The site will introduce the cause of nephrotic syndrome. The cause of nephrotic syndrome, nephrotic syndrome (nephroticsyndrome, NS) proteinuria system caused by a variety of reasons (>3.5g/d), serum albumin (<30g/L), edema and (or) clinical hyperlipidemia syndrome is a very common clinical renal diseases, treatment difficult syndrome. Nephrotic syndrome can be pided into three categories (primary, secondary and genetic diseases) (some scholars will be hereditary into secondary), can be caused by a variety of different pathological types of glomerular disease.
In accordance with the diagnostic criteria for nephrotic syndrome, it is essential to first identify, exclude, and / or identify possible causes. Diagnosis of primary nephrotic syndrome, we must seriously exclude the secondary cause of various causes: nephrotic syndrome and genetic disease caused by nephrotic syndrome can be established. Common causes of secondary nephrotic syndrome include diabetic nephropathy, systemic lupus nephritis, Henoch Schonlein purpura nephritis, renal amyloidosis, hepatitis B virus correlation. The new biological relevance of nephritis, glomerular disease, obesity related glomerulopathy and some drugs (such as non steroidal anti-inflammatory drugs, intravenous heroin) etc.. Special attention should be given to patients with nephrotic syndrome in children except genetic diseases (such as Alport syndrome, congenital nephrotic syndrome), elderly patients with nephrotic syndrome and it should focus on elimination of metabolic diseases and new biological relevance of nephrotic syndrome.
For patients with nephrotic syndrome to exclude hereditary diseases caused by nephrotic syndrome, especially in pediatric patients, should be more serious inquiry and investigation of family history, genetic way to understand the possible, should make linkage analysis and gene location when necessary. Is a common clinical syndrome of Alport patients is about 30% ~ 40% NS. deep research on podocyte molecular structure in recent years, also confirmed some nephrotic syndrome and gene mutation, such as congenital nephrotic syndrome in Finland by the NPHSl gene (located in 19q13.1, responsible for the nephrin mutation, some encoding) steroid resistant nephrotic syndrome NPHIS2 gene (located in 1q25 - 31, podocin mutation responsible for encoding). In addition, recent studies have confirmed the presence of hereditary amyloidosis and have identified mutations associated with the gene. Exclusion of genetic factors has become essential for diagnosis of primary NS the end of the procedure, although the treatment of nephrotic syndrome hereditary kidney disease caused by many effective methods, but after diagnosis to avoid excessive treatment and prevention of acquired renal damage factors, deepen for genetic counseling will be beneficial. At present, it is difficult to diagnose sporadic, non familial and nonspecific pathological findings. Alport syndrome gene mutation has no hot spots, its pathogenic gene positioning step is complex and lengthy, so it is difficult to carry out routine clinical. There is still a big gap between the diagnosis and research of hereditary kidney disease and international advanced level.

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