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What are common complications of nephrotic syndrome

Dec 27, 2016

 (1) infection: due to the loss of a large number of immunoglobulin in urine, plasma protein decreased, affecting antibody formation. The use of corticosteroids and cytotoxic drugs, so that patients with decreased systemic resistance, prone to infection, such as skin infection, primary peritonitis, respiratory tract infection, urinary tract infection, and even induce sepsis.

(2) coronary heart disease: nephrotic syndrome patients often have hyperlipidemia and hypercoagulable state, so prone to coronary heart disease. It has been reported that the incidence of myocardial infarction in patients with nephrotic syndrome is 8 times higher than that in normal subjects. Coronary heart disease has become the third cause of death of nephrotic syndrome (second only to infection and renal failure). (3) thrombosis: nephrotic syndrome prone to thrombosis, especially the incidence of membranous nephropathy of up to 25% ~ 40%. The causes of thrombus are edema, patient activity, venous stasis, high blood lipids, blood viscosity increased, the concentration of fibrinogen and high content of V, x, VII and VIII factor increases and the use of adrenal cortical hormone and prone to blood hypercoagulability.
(4): acute renal failure in patients with nephrotic syndrome due to massive proteinuria, hypoalbuminemia and hyperlipidemia, body is in a low blood test, test site collection capacity and hypercoagulable state of vomiting and diarrhea, anti hypertension medicine and plenty of diuresis, can make kidney blood perfusion suddenly the reduced glomerular filtration rate decreases, leading to acute renal failure. In addition, nephrotic syndrome renal interstitial edema, protein concentration form tubular blockage of renal tubules and other factors, can also cause acute renal failure.
(5) electrolyte and metabolic disorders: repeated use of diuretics or long-term unreasonable no salt, can make comprehensive secondary hyponatremia patients with nephropathy; use of adrenal cortical hormone and diuretics lead to a large number of micturition, if not timely supplement of potassium, prone to hypokalemia.

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