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What tests should be done to diagnose nephrotic syndrome?

May 17, 2017

What tests are needed to confirm the diagnosis of nephrotic syndrome? What is nephrotic syndrome? Tongshantang nephropathy experts explained that the nephrotic syndrome (NS) is a general term for a group of clinical symptoms, the glomerular injury is the main reason. The main characteristics are high edema, high proteinuria, hyperlipidemia and hypoproteinemia, i.e., the three highs and one low.
Therefore, there are many classifications of nephrotic syndrome, nephrotic syndrome can be pided into primary, secondary and congenital, of which congenital nephrotic syndrome is more related to genetic factors. The clinical manifestations of nephrotic syndrome are characterized by 4 large proteinuria, hypoproteinemia, hyperlipidemia, and edema. The examination of nephrotic syndrome includes routine urine test, selective proteinuria, C3 and FDP determination in urine, blood biochemical tests, and biopsy of renal tissues.
So those tests can help diagnose nephrotic syndrome?
1. urine routine: urine routine examination found that the urine of patients except for a large number of proteins, there may be transparent tube type or granular tube type, and sometimes can have fat tube type.
2. selective proteinuria and urinary C3 and FDP determination: type I is selective proteinuria, urinary C3 and FDP values normal, type II is non selective proteinuria, urinary C3 and FDP values are often more than normal.
3. blood biochemical examination: except for the decrease of plasma total protein, the White / bulb can be inverted, the blood cholesterol type I is increased, and the type II is not increased.
4. ESR rate: often 40~80mm/h, ESR growth and more edema parallel.
5. protein electrophoresis: alpha 2 or beta can be significantly increased, alpha 1, gamma globulin most low.
6. renal function tests: type I is normal, type II has different levels of abnormalities.
7. renal biopsy: ultrastructural and immunohistochemical observations can be used to provide morphological basis.
To sum up, nephrotic syndrome needs to be confirmed by the above seven examinations. Tongshantang nephropathy experts advise patients must actively check, if it is found, to actively cooperate with medical treatment, to minimize risk and recover as soon as possible.

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