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Complications of nephrotic syndrome

May 30, 2017

Nephrotic syndrome can be complicated by what disease? Infection, nephrotic syndrome in patients with decreased resistance to infection is mainly due to: the loss of large amounts of urine in the urine. B factor (complement alternative pathway components) caused by the lack of bacterial immune conditioning action defects; malnutrition, the body non-specific immune response ability weakened, resulting in impaired immune function. A large number of transferrin and zinc are lost from the urine. Transferrin is necessary to maintain normal lymphocyte function, zinc ion concentration and thymosin synthesis. Local factors. Pleural effusion, ascites, skin edema caused by high skin rupture and severe edema to dilute the local body fluid factor, defensive function weakened, are nephrotic syndrome patients susceptible factors. Before the advent of antibiotics, bacterial infection was one of the major causes of death in patients with nephrotic syndrome, severe infections occur mainly in children and the elderly, adults are rare. Common clinical infections are: primary peritonitis, cellulitis, respiratory infections and urinary tract infections. Once the infection diagnosis is established, should be treated immediately.

Hypercoagulable state and venous thrombosis, nephrotic syndrome, hypercoagulable state, mainly due to changes in blood clotting factor. Including Ⅸ, Ⅺ factor decreased, V, Ⅷ, X factor, fibrinogen, β-thromboglobulin and platelet levels increased. Platelet adhesion and increased cohesion. Antithrombin Ⅲ and antiplasmin activity decreased. Therefore, the accumulation of coagulation and procoagulant factors, anti-agglutination and anticoagulant factor decline and fibrinolysis mechanism damage, nephrotic syndrome is hypercoagulable state. Antibiotics, hormones and diuretics for the application of venous thrombosis factors, hormones play a role in coagulation protein, and diuretics to make the blood concentration, blood viscosity increased.

Acute renal failure, acute renal failure for nephrotic syndrome, the most serious complications, often need dialysis treatment. Common causes are: hemodynamic changes: nephrotic syndrome often hypoproteinemia and vascular disease, especially in elderly patients with multiple renal arteriosclerosis, blood volume and blood pressure is very sensitive, so when the acute blood loss, vomiting, Diarrhea caused by loss of body fluids, surgical damage, ascites, a large number of diuretic and the use of antihypertensive drugs, can make a further decline in blood pressure, resulting in a substantial reduction in renal perfusion, and thus reduce the glomerular filtration rate, and after acute ischemia Tubular epithelial cell swelling, degeneration and necrosis, leading to acute renal failure.

Above is the Tongshantang Medical Group experts to introduce the complications of nephrotic syndrome in all cases, on the above experts described the nephrotic syndrome disease may bring some complications to patients, nephrotic syndrome disease is a very serious merger So that for such a disease people should pay more attention to illness in time after treatment, or lead to the above complications will increase the difficulty of treatment.

Complications of nephrotic syndrome

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