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Classification of nephrotic syndrome

Dec 31, 2016
(a) clinical classification:
1 simple renal disease: the clinical features of the kidney with the characteristics of the majority of preschool children, more men than women, more sensitive to hormone therapy, but easy to relapse, four.
2 nephrosonephritis: in addition to four features with nephropathy, also has the following performance of the recurrent or persistent hypertension: preschool children was higher than that of 120/80mmHg (16.0/10.7kPa), school-age children was higher than that of 130/90mmHg (17.3/12.0kPa), except those caused by glucocorticoids. Hematuria: centrifugal urine microscopy red blood cell is greater than 10 /HP (>3 times within 2 weeks). Plasma urea nitrogen was more than 30mg/dl (10.7mmol/L), except for insufficient blood volume. The persistent hypocomplementemia.
3 congenital kidney disease: within 3 months of onset in the majority of birth or after birth with nephrotic syndrome, the majority of hormone response or adverse reactions, often in death within 6 months because of infection, renal failure and other complications after birth. Taking Finland congenital nephropathy was the most common clinical manifestations, except with nephropathy, a premature birth, breech delivery, intrauterine asphyxia, placenta (birth weight over 25%) history.
(two) according to the glucocorticoid response:
1 hormone sensitive type: to prednisone adequate treatment of urinary protein negative in less than 8 weeks.
2 steroid resistant type: hormone therapy for 8 weeks still positive urine protein.
3 hormone dependent: sensitive to hormones, but the reduction or withdrawal within 1 months of recurrence, repeat more than 2 times.
Several concepts: 1 recurrence: refers to the urine protein from Yin to Yang >2 weeks. 2 frequent relapse within half year relapse more than 2 times, 3 times a year in the aged. (three) the pathological types were: minimal lesion type (MCNS), focal stage glomerulosclerosis (FSFS), mesangial proliferative glomerulonephritis (MPGN), mesangial proliferative glomerulonephritis (MsPGN), membranous nephropathy (MN). Pathological changes of 80% cases of primary nephrotic syndrome in children.

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