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What are the typical symptoms of nephrotic syndrome

Dec 31, 2016
Nephrotic syndrome has four main features, that is, a lot of proteinuria, hypoalbuminemia, hypercholesterolemia, and significant edema.Kidney disease have a good variety of, so patients with nephrotic syndrome?Specific performance is what? 
1. A lot of a lot of albuminuria is a sign of nephrotic syndrome.Main component is albumin, plasma protein can also contain other components.Glomerular basement membrane permeability change is the basic cause of proteinuria, mechanical barrier and charge barrier changes (glomerular capillary pore size screen), renal tubular epithelial cell absorption and catabolism of ability also have influence on the formation of proteinuria.Glomerular filtration rate, concentration of plasma protein and protein intake directly affects the degree of proteinuria.Glomerular filtration rate falls, proteinuria decrease;Severe hypoalbuminemia, urine protein excretion quantity can increase, high-protein diet can increase urine protein excretion;Only with daily protein quantitative method, therefore, cannot be accurately judge the degree of urine protein, albumin can further do clearance, urinary albumin/creatinine (> 3.5 for nephrotic range proteinuria).Urine protein electrophoresis detection components in urine IgG prompt selectivity lower urinary protein.The clinical value of urine protein was no sure, has been to use less. 
2. Hypoalbuminemia second characteristics of nephrotic syndrome is necessary.Serum albumin less than 30 g/L.Nephrotic syndrome in the liver to increase albumin synthesis, when give enough protein and calorie diet, every day in patients with liver albumin synthesis is about 22.6 g, 15.6 g a day significantly increased than normal.When liver albumin compensatory effect is not enough to compensate for the loss of urine protein quantity, will appear hypoalbuminemia.Between hypoalbuminemia and urinary protein excretion is not fully consistent. 
3. Hyperlipidemia disease three acyl glycerin increased significantly, total cholesterol, low density lipoprotein (LDH), low density lipoprotein (VLDH) levels.Hyperlipidemia is associated with low serum albumin leels, LDL/HLDL only in serum albumin below 10 ~ 20 g/L to rise.High-density lipoprotein (HDL) normal or decline.LDL/HDL ratio increases, increased the risk of arteriosclerosis sex complications, hyperlipidemia associated with thrombosis and progressive glomerular sclerosis. 
4. The symptoms of patients with edema, the most notable is gradually increasing anasarca, initial morning eyelid, facial, visible ankle edema;Edema development as the illness spread to the whole body, and pleural effusion, ascites, pericardial effusion, mediastinal effusion, scrotal edema or labia, also can appear pulmonary edema.Severe cases can't open my eyes, head and neck coarsens, skin can show waxy pallor, together with the chest, the presence of ascites, so the apparent difficulty breathing, cannot lay down only sitting position.Above for doctors in detail, the performance of patients with kidney disease to observe their body in time, do more inspection, if there is the phenomenon to timely medical treatment.Determine presence of complications, especially merge infection, thrombosis, and acute renal failure, should be timely judgments.

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