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Common secondary nephrotic syndrome

Dec 31, 2016
1 allergic purpura nephritis
In children and adolescents. A typical skin rash, with joint pain, abdominal pain and melena, often in a rash after 1~4 weeks of hematuria and proteinuria, some patients presented nephrotic syndrome, renal biopsy for mesangial proliferative glomerulonephritis, mesangial IgA and complement C3 showed granular deposition. Typical skin rash can prompt the diagnosis of the disease, renal biopsy pathological examination can further help diagnosis.
2 lupus nephritis
Good hair in green, middle-aged women. Often have fever, rash (Butterfly erythema and light allergy), oral mucous membrane ulcer, joint pain, multiple inflammation and multiple organ system (heart, kidney, blood and nerve) tired performance. The test of serum complement receptor C3 decreased, a variety of autoantibodies, renal involvement in patients with nephrotic syndrome. Lupus nephritis (IV) (V) (type of membrane) is a kind of lupus nephritis with nephrotic syndrome. Lupus nephritis must rely on renal biopsy pathological typing.
3 diabetic nephropathy
In the middle and old age. Suffering from diabetes for several years will appear renal damage, the initial presentation of albuminuria, and gradually progressed to a large number of proteinuria, nephrotic syndrome occurs when the disease has reached more than 10 years. Since then, the disease progressed faster, 35 years into uremia. The typical pathological features of this disease are nodular or diffuse glomerulosclerosis. Because there are more than 10 years before the onset of nephrotic syndrome in patients with diabetes history, so it is not easy to misdiagnosis, missed diagnosis.
4 renal amyloidosis
In the middle and old age. Amyloidosis is pided into primary and secondary two kinds, the pathogeny is not clear, mainly involving heart, kidney and digestive tract (including the tongue), skin and nerve; the latter often secondary to chronic suppurative infection and malignant tumors and other diseases, mainly involving kidney and liver and spleen. The volume of renal involvement was increased, and nephrotic syndrome often occurred. The pathological diagnosis of the disease needs to be done by biopsy (gingival, tongue, rectum, kidney or liver biopsy). The pathological changes of the tissues are positive for Congo red staining.
5 myeloma kidney damage
Good hair in the middle and old age, male than female. Often has the following performance: bone pain, flat X punched out hole, serum monoclonal immunoglobulin increased, protein electrophoresis increased, M urine protein electrophoresis band, gelsolin positive myeloma can cause a variety of kidney damage, when a large number of light chain protein deposition in glomeruli (light chain nephropathy) or with renal amyloidosis. Clinical often appear in nephrotic syndrome. Based on the typical performance of myeloma is not difficult to determine, myeloma patients appear abnormal urine, renal puncture should be done to determine the nature of kidney.

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