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What are the factors leading to uremia exacerbations

Dec 30, 2016
This is a problem plagued a lot of patients, a lot of patients: "I usually have a good maintenance, but also pay attention to their own body, why the condition is also increased?" Care and maintenance of normal deterioration of uremia is a certain role, but for the maintenance of the method may be a lot of patients can't catch on, often counterproductive, experts in our hospital summed up several reasons causing uremia exacerbations, hope that patients can better effective care of our body, prevention of illness.
Cause the aggravation of uremia:
(1) insufficient blood volume such as bleeding, gastrointestinal bleeding, long-term excessive use of diuretics, vomiting, diarrhea can cause blood volume and severe edema absolutely insufficient; can be caused by insufficient effective blood volume. All of these factors can lead to insufficient blood volume in the kidney, which can lead to further deterioration of renal function.
(2) the use of nephrotoxic drugs such as aminoglycoside antibiotics, iodine contrast agents, non steroidal anti-inflammatory drugs, etc., can aggravate uremia, especially in the case of insufficient capacity is particularly easy to occur.
(3) the obstructive factors include renal obstruction and renal obstruction. The former is mainly caused by the deposition of uric acid crystals and so on.
(4) the immune system of patients with uremia is decreased, which can be easily combined with infection, including systemic infection and local urinary tract infection. After infection, the body weight was increased, and the renal function deteriorated. The formation of a vicious cycle, is a very common cause of uremia aggravating factors.
(5) whether hypertension is poorly controlled hypertension and secondary hypertension, can cause renal arterioles especially the afferent arteriole spasm, resulting in decreased renal blood flow caused by the deterioration of renal function. At the same time, poor control of hypertension can also lead to heart failure, further aggravate the decline in renal blood flow and lead to deterioration of uremia.
(6) water, electrolyte and acid-base balance in patients with uremia, water, electrolyte, acid-base balance is very important, is the important factor to maintain basic vital signs of patients, when patients with excessive water loss, water excessive, hypernatremia or hyponatremia, hyperkalemia or hypokalemia may be due to increased kidney load, affects the whole body effective blood volume and cardiac function caused by the deterioration of renal function. Uremia patients due to abnormal metabolism of the kidney, excretion function is often accompanied by hyperkalemia, acidosis, which can further deterioration of renal function, resulting in a vicious cycle.
(7) a high protein diet and proteinuria in many have entered uremia patients with chronic kidney disease, there are still a lot of proteinuria, in the dialysis treatment before continuing high protein diet, while the degree of proteinuria will increase, can cause further damage to the glomerular basement membrane, and the kidney function deterioration.
(8) heart diseases such as congestive heart failure or cardiac tamponade can affect systemic blood volume and the renal insufficient effective blood volume; on the other hand, in the heart failure usually accompanied by systemic reflux disorder, the kidney is in congestion state, also aggravate uremia.
(9) high catabolic state in uremic patients in surgery, gastrointestinal bleeding, fever, high dose glucocorticoid therapy, the body is in continuous high catabolic state, metabolic toxins produce more kidney can not be discharged and the aggravation of uremia

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